Description

Fmoc-Sar-Opfp CAS NO 159631-29-5 is a specialized N-Fmoc-protected amino acid derivative activated with pentafluorophenyl (OPfp) ester. This compound is a critical building block in solid-phase peptide synthesis (SPPS), offering enhanced coupling efficiency and reduced racemization risk. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel peptides, peptidomimetics, and bioconjugates.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an activated ester for the efficient incorporation of sarcosine (N-methylglycine) into peptide chains.
• Peptidomimetic Research: For the synthesis of peptide analogs with modified backbones to enhance metabolic stability and bioavailability.
• Bioconjugation: Used in the preparation of peptide-protein or peptide-small molecule conjugates for drug delivery and diagnostic applications.
• Combinatorial Chemistry: A key reagent in the generation of diverse peptide libraries for high-throughput screening.
• Academic & Industrial R&D: Fundamental research tool in medicinal chemistry and chemical biology for probing protein function and interactions.
• API Intermediate: Potential use as an intermediate in the synthesis of complex peptide-based Active Pharmaceutical Ingredients (APIs).

Basic Information

Product Name	Fmoc-Sar-Opfp
CAS No.	159631-29-5
Molecular Formula	C24H16F5NO5
Molecular Weight	493.38 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methylglycine pentafluorophenyl ester; Fmoc-Sarcosine pentafluorophenyl ester; Fmoc-N-methylglycine OPfp ester; N-Fmoc-sarcosine pentafluorophenyl ester; (9H-Fluoren-9-yl)methyl N-methyl-N-[(2,3,4,5,6-pentafluorophenoxy)carbonyl]glycinate; Fmoc-Sar-OPfp
EINECS	Contact for details

Quality Control

Our Fmoc-Sar-Opfp is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, essential for sensitive peptide synthesis applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our customers' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.