Description

Fmoc-(S)-2-Amino-3-Methoxypropionic Acid is a protected, non-proteinogenic amino acid derivative essential for solid-phase peptide synthesis (SPPS). This chiral building block is critical for introducing methoxy-substituted alanine analogs into peptide chains, enabling the creation of novel structures with modified properties. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of peptide-based therapeutics, diagnostics, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of custom peptides.
• Pharmaceutical Research: Incorporation into peptide drug candidates to study the effects of side-chain methoxylation on bioactivity, stability, and pharmacokinetics.
• Bioconjugation & Probe Development: Serving as a versatile intermediate for creating labeled peptides or peptide-protein conjugates for diagnostic assays.
• Material Science: Used in the synthesis of peptidomimetics and functional polymers where controlled chirality and side-chain functionality are required.
• Academic & Industrial R&D: A fundamental reagent for exploring structure-activity relationships (SAR) in medicinal chemistry projects.

Basic Information

Product Name	Fmoc-(S)-2-Amino-3-Methoxypropionic Acid
CAS No.	159610-93-2
Molecular Formula	C19H19NO5
Molecular Weight	341.36 g/mol
Synonyms	Fmoc-Methoxyalanine-OH; Fmoc-3-Methoxy-L-alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methoxy-L-alanine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-methoxypropanoic acid; Fmoc-L-3-Methoxyalanine; Fmoc-MeO-Ala-OH; N-Fmoc-3-methoxy-L-alanine; Fmoc-β-methoxy-L-alanine
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-2-Amino-3-Methoxypropionic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity verification, to ensure it meets the high standards required for sensitive peptide synthesis applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee reproducible performance and supply chain reliability for your critical R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.