Description

Fmoc-L-Styrylalanine CAS NO 159610-82-9 is a high-purity, non-natural amino acid derivative featuring a photolabile styryl side chain, protected by the versatile 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is critical for the solid-phase synthesis of peptides and peptidomimetics, enabling the precise incorporation of a light-sensitive moiety for applications in photochemistry and bioconjugation. It is an essential building block for researchers and manufacturers in pharmaceutical development, chemical biology, and materials science who require advanced, functionalized amino acids for creating novel bioactive compounds and smart materials.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected amino acid for the Fmoc-strategy synthesis of peptides containing photolabile or cross-linkable styrylalanine residues.
• Photopharmacology & Photodynamic Therapy: Used to synthesize peptide-based prodrugs or therapeutic agents where light-triggered activation or release is required.
• Bioconjugation & Probe Development: Serves as a precursor for creating fluorescent probes, affinity labels, or bioconjugation handles with light-responsive properties.
• Materials Science: Incorporated into polymers and smart materials to introduce photo-responsive behavior for controlled degradation or property changes.
• Structural Biology Studies: Utilized to engineer proteins and peptides with site-specific, photo-crosslinking capabilities for studying protein-protein interactions.
• Pharmaceutical Intermediate: An important chiral synthon in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).

Basic Information

Product Name	Fmoc-L-Styrylalanine
CAS No.	159610-82-9
Molecular Formula	C26H23NO4
Molecular Weight	413.46 g/mol
Synonyms	Fmoc-L-2-Amino-3-(2-phenylethenyl)propanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-styrylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl]amino-3-[(E)-2-phenylethenyl]propanoic acid; Fmoc-Styr-OH; Fmoc-L-β-(2-Phenylethenyl)alanine; N-Fmoc-L-styrylalanine; Fmoc-L-(E)-Styrylalanine; Fmoc-L-3-(2-Phenylethenyl)alanine
EINECS	Contact for details

Quality Control

Our Fmoc-L-Styrylalanine is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for research and pharmaceutical applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, chiral integrity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.