Description

(p-Iodo-Phe)-Acth (4-10) CAS NO 159600-82-5 is a synthetic peptide fragment derived from the adrenocorticotropic hormone (ACTH), specifically modified with a para-iodinated phenylalanine residue. This targeted modification is crucial for research applications requiring enhanced stability, specific receptor binding studies, or radiolabeling potential. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on neuroendocrinology, peptide chemistry, and diagnostic probe development.

Application

• Neuroscientific Research: Used as a tool compound to study the structure-activity relationship (SAR) of ACTH fragments and their interaction with melanocortin receptors.
• Biochemical Assay Development: Serves as a reference standard or a modified substrate in enzymatic and binding assays due to its iodinated tag.
• Diagnostic Probe Precursor: The iodine moiety provides a potential site for radioiodination (e.g., with I-125), enabling its use in the development of imaging agents or radioligands.
• Peptide Chemistry & Conjugation Studies: Acts as a model peptide for studying modification strategies, stability, and conjugation techniques in aqueous and organic media.
• Pharmaceutical Intermediate: Employed in the research and development of novel peptide-based therapeutics targeting central nervous system disorders.

Basic Information

Product Name	(p-Iodo-Phe)-Acth (4-10)
CAS No.	159600-82-5
Molecular Formula	C46H62N12O10SI
Molecular Weight	1085.1 g/mol
Synonyms	ACTH (4-10), Iodinated; [p-Iodo-Phe7]-ACTH (4-10); Adrenocorticotropic Hormone (4-10) fragment, 7-(p-Iodo-Phenylalanine); H-Met-Glu-His-Phe-Arg-Trp-pI-Phe-OH; Melanocortin receptor ligand fragment; Iodo-ACTH (4-10); pI-Phe7-ACTH (4-10)
EINECS	Contact for details

Quality Control

Every batch of (p-Iodo-Phe)-Acth (4-10) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality assurance protocol is designed to meet the exacting standards of research and development. A comprehensive Certificate of Analysis (COA) detailing purity (by HPLC), peptide content, and related substances is provided with each shipment to support your regulatory and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0%
Single Impurity (HPLC)	≤ 2.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.