Description

(2S,3R)-1-(Diphenylmethyl)-2-Methylazetidine-3-Carbonitrile is a high-purity chiral azetidine derivative, a key structural motif in advanced pharmaceutical synthesis. This compound serves as a critical chiral building block or intermediate for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring stereochemical precision. It is essential for research and process chemists in the pharmaceutical and fine chemical industries focused on asymmetric synthesis and drug discovery.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug molecules, particularly those targeting the central nervous system or as enzyme inhibitors.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in stereoselective chemical transformations to introduce the azetidine ring system with defined stereochemistry.
• Medicinal Chemistry Research: Serves as a scaffold for constructing compound libraries in high-throughput screening and structure-activity relationship (SAR) studies.
• Process Development: Used in the scale-up and optimization of synthetic routes for candidate drugs during clinical development phases.
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals and advanced materials requiring the azetidine moiety.

Basic Information

Product Name	(2S,3R)-1-(Diphenylmethyl)-2-Methylazetidine-3-Carbonitrile
CAS No.	159556-79-3
Molecular Formula	C19H20N2
Molecular Weight	276.38 g/mol
Synonyms	rel-(2S,3R)-1-(Diphenylmethyl)-2-methylazetidine-3-carbonitrile; 1-(Benzhydryl)-2-methyl-3-cyanoazetidine (stereoisomer); Azetidine-3-carbonitrile, 1-(diphenylmethyl)-2-methyl-, (2S,3R)-rel-; (rel)-(2S,3R)-1-(Diphenylmethyl)-2-methylazetidine-3-carbonitrile; 159556-79-3; Benzhydryl 2-methylazetidine-3-carbonitrile derivative
EINECS	Contact for details

Quality Control

Our (2S,3R)-1-(Diphenylmethyl)-2-Methylazetidine-3-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity assessment by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and stereochemical integrity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.