Description

Cbz-S-Phenyl-L-Cysteine CAS NO 159453-24-4 is a protected derivative of the amino acid L-cysteine, featuring a carboxybenzyl (Cbz) protecting group on the amine and a phenylthioether moiety. This compound is a crucial chiral building block and intermediate in the synthesis of complex peptides, peptidomimetics, and active pharmaceutical ingredients (APIs). It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and production of peptide-based therapeutics and other bioactive molecules.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate modified cysteine residues, influencing peptide structure and stability.
• Drug Discovery & Medicinal Chemistry: Serves as a versatile building block for creating compound libraries and exploring structure-activity relationships (SAR) in new drug candidates.
• Bioconjugation & Chemical Biology: The reactive thioether group can be utilized for site-specific labeling or cross-linking applications in probe and antibody-drug conjugate (ADC) development.
• Protecting Group Strategy: The Cbz group allows for orthogonal deprotection in multi-step synthetic routes, enabling complex molecular assembly.
• Catalyst & Ligand Preparation: Can be used to synthesize chiral ligands or organocatalysts for asymmetric synthesis.

Basic Information

Product Name	Cbz-S-Phenyl-L-Cysteine
CAS No.	159453-24-4
Molecular Formula	C₁₇H₁₇NO₄S
Molecular Weight	331.38 g/mol
Synonyms	N-Carbobenzoxy-S-phenyl-L-cysteine; N-Cbz-S-phenyl-L-cysteine; (R)-2-(((Benzyloxy)carbonyl)amino)-3-(phenylthio)propanoic acid; Z-S-Phenyl-L-cysteine; Nα-Carbobenzyloxy-S-phenyl-L-cysteine; N-[(Benzyloxy)carbonyl]-S-phenyl-L-cysteine; L-Cysteine, N-[(phenylmethoxy)carbonyl]-S-phenyl-; N-Cbz-S-Ph-L-Cys-OH
EINECS	Contact for details

Quality Control

Our Cbz-S-Phenyl-L-Cysteine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR). We provide full traceability and a Certificate of Analysis (COA) with every shipment, ensuring compliance with research and cGMP-grade requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. The product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.