Description

n-[(1,1-Dimethylethoxy)Carbonyl]-4-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-D-Phenylalanine Methyl Ester is a protected amino acid derivative, specifically a Boc-protected D-phenylalanine analog, serving as a critical chiral building block in advanced organic synthesis. Its value lies in providing a stereochemically pure and orthogonally protected intermediate, enabling the precise construction of complex peptide and peptidomimetic structures. This compound is essential for research and development chemists in the pharmaceutical and biotechnology sectors, particularly for the synthesis of active pharmaceutical ingredients (APIs), peptide-based therapeutics, and novel drug candidates.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex peptide-based Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) for the controlled incorporation of D-phenylalanine derivatives into peptide chains.
• Peptidomimetic Research: Serves as a building block for creating non-natural peptide analogs (peptidomimetics) with enhanced metabolic stability and bioavailability.
• Protease Inhibitor Development: Employed in the research and synthesis of protease inhibitors, where the D-amino acid configuration is crucial for activity.
• Chemical Biology Probes: Utilized in the synthesis of labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Asymmetric Synthesis: Acts as a source of chiral induction in the synthesis of more complex, non-peptide molecules requiring specific stereochemistry.

Basic Information

Item	Details
Product Name	n-[(1,1-Dimethylethoxy)Carbonyl]-4-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-D-Phenylalanine Methyl Ester
CAS No.	159184-22-2
Molecular Formula	C21H30N2O6
Molecular Weight	406.48 g/mol
Synonyms	Boc-D-Phe(4-NH-Boc)-OMe; Methyl (2R)-2-[(tert-butoxy)carbonylamino]-3-[4-[(tert-butoxy)carbonylamino]phenyl]propanoate; Boc-4-NH-Boc-D-Phenylalanine Methyl Ester; D-Phenylalanine, N-[(1,1-dimethylethoxy)carbonyl]-4-[[(1,1-dimethylethoxy)carbonyl]amino]-, methyl ester; (R)-Methyl 2-((tert-butoxycarbonyl)amino)-3-(4-((tert-butoxycarbonyl)amino)phenyl)propanoate; 4-N-Boc-D-Phenylalanine(4-N-Boc) Methyl Ester; Boc-D-Phe(4-NHBoc)-OCH3
EINECS	Contact for details

Quality Control

Our n-[(1,1-Dimethylethoxy)Carbonyl]-4-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-D-Phenylalanine Methyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical R&D and cGMP applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.