Description

(S)-2-((R)-2-Chloropropanamido)-4-Carbamoylbutanoic Acid is a high-purity chiral building block and synthetic intermediate of significant interest in advanced pharmaceutical research and development. Its precise stereochemistry makes it a valuable precursor for the synthesis of complex, biologically active molecules, particularly in the creation of novel active pharmaceutical ingredients (APIs). This compound is primarily utilized by research institutions, contract development and manufacturing organizations (CDMOs), and pharmaceutical companies engaged in the development of peptide-based therapeutics and other specialized fine chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting neurological and metabolic disorders.
• Peptidomimetic Research: Serves as a key building block for constructing peptide analogs and mimetics with enhanced stability and bioavailability.
• API Development: Used in the research and process development stages for new Active Pharmaceutical Ingredients (APIs), leveraging its defined stereocenters.
• Asymmetric Synthesis: Employed in academic and industrial research focused on novel asymmetric catalytic reactions and methodologies.
• Bioconjugation Chemistry: Potential use in the development of antibody-drug conjugates (ADCs) and other targeted therapeutic modalities due to its functional handles.
• Chemical Biology Probes: Acts as a precursor for designing molecular probes to study enzyme function and biological pathways.

Basic Information

Product Name	(S)-2-((R)-2-Chloropropanamido)-4-Carbamoylbutanoic Acid
CAS No.	159141-33-0
Molecular Formula	C9H15ClN2O4
Molecular Weight	250.68 g/mol
Synonyms	L-Glutamine, N-[(1R)-1-chloro-2-oxopropyl]-; (2S)-2-[[(2R)-2-Chloropropanoyl]amino]-4-carbamoylbutanoic acid; N-[(2R)-2-Chloropropionyl]-L-glutamine; (S)-2-((R)-2-Chloropropionamido)-4-carbamoylbutyric Acid; (S)-2-((R)-2-Chloropropanamido)-4-Carbamoylbutanoic Acid; 159141-33-0; N-[(R)-2-Chloropropionyl]glutamine
EINECS	Contact for details

Quality Control

Our (S)-2-((R)-2-Chloropropanamido)-4-Carbamoylbutanoic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support development projects with material produced under current Good Manufacturing Practice (cGMP) guidelines for non-clinical and clinical-stage applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]	Contact for details
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.