Description

Desmethylene Paroxetine Hydrochloride Salt is a key pharmaceutical intermediate in the synthesis of active pharmaceutical ingredients (APIs). This compound is of significant commercial importance for its role in the production of high-value therapeutic agents. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development and production of advanced drug formulations.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of paroxetine analogs and related active pharmaceutical ingredients (APIs).
• Research & Development: Used in medicinal chemistry research for the development of new therapeutic compounds targeting the central nervous system.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of pharmaceutical products.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory compliance testing in pharmaceutical labs.
• Fine Chemical Synthesis: Utilized in the preparation of complex organic molecules requiring this specific structural motif.

Basic Information

Item	Detail
Product Name	Desmethylene Paroxetine Hydrochloride Salt
CAS No.	159126-30-4
Molecular Formula	C₁₉H₂₀FNO₃ • HCl
Molecular Weight	365.83 g/mol
Synonyms	(-)-trans-4-(4-Fluorophenyl)-3-[[3,4-(methylenedioxy)phenoxy]methyl]piperidine Hydrochloride; Paroxetine Desmethylene Hydrochloride; Paroxetine Impurity; 4-(4-Fluorophenyl)-3-[(3,4-methylenedioxyphenoxy)methyl]piperidine Hydrochloride; UNII-9K5X8FQ0Q5; 159126-30-4 (Hydrochloride Salt); Paroxetine Related Compound
EINECS	Contact for details

Quality Control

Our Desmethylene Paroxetine Hydrochloride Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific customer or regulatory requirements, such as ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.