Description

(R)-(-)-1-[(S)-2-(Dicyclohexylphosphino)Ferrocenyl]Ethyldi-T-Butylphosphine CAS NO 158923-11-6 is a highly specialized, chiral ferrocenyl phosphine ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to impart exceptional enantioselectivity and catalytic activity in a range of transition-metal-catalyzed reactions, enabling the efficient synthesis of single-enantiomer compounds. This ligand is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for developing new active ingredients and advanced intermediates.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, critical for producing chiral alcohols and amines in pharmaceutical synthesis.
• Cross-Coupling Reactions: Enhances selectivity and yield in asymmetric Suzuki-Miyaura, Negishi, and Buchwald-Hartwig amination reactions for constructing complex, chiral biaryl and C-N bond frameworks.
• Asymmetric Allylic Substitution: Used in Tsuji-Trost and related reactions to create chiral carbon-carbon and carbon-heteroatom bonds with high regio- and enantiocontrol.
• Pharmaceutical Intermediate Synthesis: Key catalyst component for manufacturing enantiomerically pure active pharmaceutical ingredients (APIs) and advanced intermediates.
• Agrochemical Product Development: Enables the synthesis of chiral herbicides, fungicides, and plant growth regulators with improved efficacy and environmental profiles.
• Academic & Industrial R&D: A vital tool for methodological development in organic synthesis and catalysis research within university and corporate laboratories.

Basic Information

Product Name	(R)-(-)-1-[(S)-2-(Dicyclohexylphosphino)Ferrocenyl]Ethyldi-T-Butylphosphine
CAS No.	158923-11-6
Molecular Formula	C32H48FeP2
Molecular Weight	550.52 g/mol
Synonyms	(R)-(-)-1-[(S)-2-(Dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; Josiphos SL-J009-1; (R)-(S)-Josiphos; (R)-1-[(S)-2-(Dicyclohexylphosphino)ferrocenyl]ethyldi(tert-butyl)phosphine; (R)-1-[(S)-2-(Dicyclohexylphosphino)ferrocenyl]ethylbis(1,1-dimethylethyl)phosphine; (R)-1-[(S)-2-(Dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; (R)-1-[(S)-2-(Dicyclohexylphosphino)ferrocenyl]ethyldi(tert-butyl)phosphate; Chiral Josiphos Ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is produced and tested under strict quality management protocols to ensure consistency and performance. Standard quality verification includes HPLC for chiral purity and assay, NMR for structural confirmation, and ICP-MS for trace metal analysis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to maintain stability and prevent oxidation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.