Description

(S,S)-1-Dicyclohexylphosphino-2-[1-(Dicyclohexylphosphino)Ethyl]Ferrocene CAS NO 158923-07-0 is a high-value, chiral ferrocenyl diphosphine ligand, a cornerstone in modern asymmetric catalysis. Its primary value lies in enabling highly enantioselective transformations, crucial for producing single-isomer pharmaceuticals and fine chemicals with superior purity and efficacy. This ligand is essential for research and production chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control in hydrogenation, cross-coupling, and other transition metal-catalyzed reactions.

Application

• Asymmetric Hydrogenation: A premier ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones, critical for synthesizing chiral active pharmaceutical ingredients (APIs) and intermediates.
• Pharmaceutical Synthesis: Enables the production of single-enantiomer drugs for therapeutic areas such as oncology, cardiology, and central nervous system disorders, where chirality dictates biological activity.
• Agrochemical Manufacturing: Used in the synthesis of chiral herbicides, fungicides, and pesticides, where the specific isomer often provides enhanced efficacy and environmental safety.
• Cross-Coupling Reactions: Facilitates asymmetric C-C and C-X bond-forming reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings, to construct complex chiral molecules.
• Academic & Industrial R&D: A vital tool for methodology development and process chemistry optimization in both university laboratories and industrial R&D centers.
• Fine Chemical Production: Applied in the manufacture of high-value chiral flavors, fragrances, and electronic chemicals requiring specific stereochemistry.

Basic Information

Product Name	(S,S)-1-Dicyclohexylphosphino-2-[1-(Dicyclohexylphosphino)Ethyl]Ferrocene
CAS No.	158923-07-0
Molecular Formula	C36H56FeP2
Molecular Weight	606.62 g/mol
Synonyms	(S,S)-DIPAMP-Fc; (S,S)-Josiphos SL-J009-1; (S,S)-1-[2-(Dicyclohexylphosphino)ethyl]-2-(dicyclohexylphosphino)ferrocene; (S,S)-2-[1-(Dicyclohexylphosphino)ethyl]-1-dicyclohexylphosphinoferrocene; (S,S)-1-[2-(Bis(cyclohexyl)phosphino)ethyl]-2-(bis(cyclohexyl)phosphino)ferrocene; (S,S)-Dicyclohexyl(ferrocenylethyl)phosphine; SL-J009-1; Josiphos-type ligand SL-J009-1
EINECS	Contact for details

Quality Control

Our production of (S,S)-1-Dicyclohexylphosphino-2-[1-(Dicyclohexylphosphino)Ethyl]Ferrocene adheres to stringent quality protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and elemental analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), chiral purity (enantiomeric excess), and impurity profile is provided with every shipment, supporting cGMP and ISO 9001 compliant workflows for our global partners.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized and moisture-sensitive; the container should be flushed with inert gas after each opening to maintain integrity.

Specification

Item	Specification
Appearance	Orange to red-brown powder or crystals
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.