Description

n-Boc-S-Tritylcystein-n-Methoxy-n-Methylamide is a sophisticated, multi-protected cysteine derivative designed for advanced peptide synthesis. This compound matters because it provides orthogonal protection for both the thiol and amine functionalities, enabling precise, sequential deprotection strategies critical for constructing complex peptides and peptidomimetics. It is primarily needed by research chemists and process development scientists in the pharmaceutical and biotechnology industries for the development of novel therapeutic peptides, protein engineering, and as a key building block in medicinal chemistry.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key, protected amino acid building block for the controlled incorporation of cysteine residues.
• Solution-Phase Peptide Synthesis: For the synthesis of complex peptide sequences and cyclic peptides requiring selective deprotection.
• Peptidomimetic Drug Discovery: Enables the creation of stable, drug-like analogs by providing a scaffold for side-chain modification.
• Chemical Biology Research: Used in the synthesis of peptide probes, enzyme inhibitors, and protein interaction studies.
• Process Development for API Manufacturing: Serves as a critical intermediate in the scalable synthesis of peptide-based Active Pharmaceutical Ingredients (APIs).
• Conjugation Chemistry: The protected thiol group allows for site-specific conjugation with maleimides, halogens, or other reactive handles after deprotection.

Basic Information

Product Name	n-Boc-S-Tritylcystein-n-Methoxy-n-Methylamide
CAS No.	158861-38-2
Molecular Formula	C31H36N2O4S
Molecular Weight	532.70 g/mol
Synonyms	Boc-Cys(Trt)-N-OMe, N-Me; N-(tert-Butoxycarbonyl)-S-trityl-L-cysteine N-methoxy-N-methylamide; Boc-Cys(Trt)-N(OMe)Me; (2R)-2-[(tert-Butoxycarbonyl)amino]-3-(tritylsulfanyl)-N-methoxy-N-methylpropanamide; Boc-L-Cys(Trt)-N-OMe,N-Me Amide; N-Boc-S-trityl-L-cysteine N'-methoxy-N'-methylamide; L-Cysteine, N-[(1,1-dimethylethoxy)carbonyl]-S-(triphenylmethyl)-, N-methoxy-N-methylamide; Boc-Cys(Trt)-N(OMe)Me
EINECS	Contact for details

Quality Control

Our n-Boc-S-Tritylcystein-n-Methoxy-n-Methylamide is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced to meet high standards for chemical synthesis, specific compliance with pharmacopeial monographs (e.g., USP, EP) can be discussed for custom projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 97.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.