Description

2,10-Dihydroxytrimipramine is a key metabolite and reference standard of the tricyclic antidepressant trimipramine. This compound is essential for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and the development of analytical methods. It serves as a critical tool for scientists and quality control professionals in the pharmaceutical and life sciences industries who require high-purity reference materials for method validation and impurity profiling.

Application

• Pharmaceutical Reference Standard: Primary use as a certified reference material (CRM) for the quantitative and qualitative analysis of trimipramine and its metabolites.
• Metabolite Studies: Critical for in-vitro and in-vivo metabolism research to understand the biotransformation pathways of trimipramine.
• Analytical Method Development: Used to develop, validate, and calibrate HPLC, LC-MS, and GC-MS methods in bioanalytical and quality control laboratories.
• Impurity Profiling: Acts as a known impurity standard to monitor and control the quality of trimipramine active pharmaceutical ingredient (API) and finished drug products.
• Pharmacokinetic Research: Employed in studies to determine absorption, distribution, metabolism, and excretion (ADME) profiles.
• Clinical Toxicology: Used as a calibrant in forensic and clinical toxicology testing for the accurate identification and quantification of trimipramine and related compounds.

Basic Information

Item	Details
Product Name	2,10-Dihydroxytrimipramine
CAS No.	158798-75-5
Molecular Formula	C20H26N2O2
Molecular Weight	326.44 g/mol
Synonyms	2,10-Dihydroxytrimipramine; 10,11-Dihydroxytrimipramine; 2-Hydroxy-10-hydroxytrimipramine; Trimipramine metabolite; 5-[3-(Dimethylamino)-2-methylpropyl]-10,11-dihydro-5H-dibenzo[b,f]azepine-2,10-diol
EINECS	Contact for details

Quality Control

Every batch of 2,10-Dihydroxytrimipramine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and strength, meeting the rigorous standards required for pharmaceutical reference materials. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting results for assay, related substances, residual solvents, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F), in a dry environment. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.