Description

Clamikalant CAS NO 158751-64-5 is a high-purity, non-peptidic small molecule compound of significant interest in pharmaceutical research and development. This compound serves as a potent and selective inhibitor of specific ion channels, making it a valuable pharmacological tool for studying cardiac electrophysiology and related pathways. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) engaged in cardiovascular drug discovery, safety pharmacology, and basic scientific research.

Application

• Cardiovascular Research: Used as a reference standard and pharmacological probe in studies of atrial and ventricular arrhythmias.
• Drug Discovery & Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in preclinical research for novel antiarrhythmic agents.
• Safety Pharmacology: Employed in hERG channel binding assays and other tests to evaluate the cardiac safety profile of new chemical entities.
• Biochemical Assays: Acts as a specific inhibitor in enzymatic and cellular assays to elucidate ion channel function and signaling mechanisms.
• Academic Research: Utilized in university and institutional labs for fundamental studies in electrophysiology and molecular pharmacology.

Basic Information

Product Name	Clamikalant
CAS No.	158751-64-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Clamikalant; HMR 1098; HMR-1098; 1-[[5-[2-(5-Chloro-2-methoxyphenyl)ethyl]-2-furanyl]methyl]-1H-benzimidazole; 1-[[5-[2-(5-Chloro-2-methoxyphenyl)ethyl]-2-furanyl]methyl]benzimidazole; 1-({5-[2-(5-Chloro-2-methoxyphenyl)ethyl]furan-2-yl}methyl)-1H-benzimidazole
EINECS	Contact for details

Quality Control

Our Clamikalant is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including identification (IR, NMR), purity assay (HPLC), and control of specified impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with customer specifications and relevant research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.