Description

(R)-(-)-Hydroxy Chloroquine Diphosphate is a high-purity chiral intermediate and active pharmaceutical ingredient (API) of significant importance in pharmaceutical research and development. This compound matters as a key stereospecific building block for the synthesis of novel therapeutics, where the specific (R)- configuration is critical for biological activity and metabolic pathway studies. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in advanced medicinal chemistry, enantioselective synthesis, and the development of targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A critical chiral precursor for the synthesis of novel antimalarial and antiviral drug candidates.
• Enantioselective Synthesis: Used in research to study structure-activity relationships (SAR) and develop stereospecific therapeutic agents.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Research: Employed in in-vitro studies to investigate the mechanism of action and metabolic pathways of chloroquine derivatives.
• API Development: Utilized in the formulation development and pre-clinical studies of new chemical entities (NCEs).

Basic Information

Item	Details
Product Name	(R)-(-)-Hydroxy Chloroquine Diphosphate
CAS No.	158749-75-8
Molecular Formula	C₁₈H₂₆ClN₃O • 2H₃PO₄
Molecular Weight	515.86 g/mol (free base: 319.87 g/mol)
Synonyms	(R)-Hydroxychloroquine Diphosphate; (R)-HCQ Diphosphate; (R)-2-[[4-[(7-Chloro-4-quinolyl)amino]pentyl](ethyl)amino]ethanol Diphosphate; (R)-Enantiomer of Hydroxychloroquine Diphosphate; (R)-Plaquenil Intermediate; AR155495 (related code); (R)-(-)-Form
EINECS	Contact for details

Quality Control

Our (R)-(-)-Hydroxy Chloroquine Diphosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee identity, purity, and consistency, supporting your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (anhydrous basis)
Chiral Purity (Enantiomeric Excess)	≥99.0% ee (by chiral HPLC)
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.