Description

Boc-D-3-Nitrophenylalanine CAS NO 158741-21-0 is a protected, non-natural amino acid derivative featuring a nitro-substituted aromatic side chain. This compound is a critical chiral building block in the synthesis of complex peptides and peptidomimetics, where it introduces specific steric and electronic properties. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers engaged in drug discovery, development of enzyme inhibitors, and the creation of specialized bioactive molecules.

Application

• Pharmaceutical Intermediates: A key chiral synthon for the research and development of novel therapeutic peptides and protease inhibitors.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate a nitro-phenylalanine residue with defined stereochemistry (D-configuration).
• Chemical Biology Probes: Serves as a building block for creating labeled peptides or activity-based probes to study enzyme function and protein-protein interactions.
• Material Science: Potential monomer for the synthesis of specialized polymers and functionalized surfaces with aromatic nitro groups for further chemical modification.
• Academic & Industrial R&D: Employed in medicinal chemistry programs for structure-activity relationship (SAR) studies and library synthesis.

Basic Information

Product Name	Boc-D-3-Nitrophenylalanine
CAS No.	158741-21-0
Molecular Formula	C₁₄H₁₈N₂O₆
Molecular Weight	310.31 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)amino)-3-(3-nitrophenyl)propanoic acid; Boc-D-3-NO₂-Phe-OH; N-(tert-Butoxycarbonyl)-3-nitro-D-phenylalanine; D-3-Nitrophenylalanine N-Boc derivative; Boc-D-β-(3-Nitrophenyl)alanine; N-Boc-3-nitro-D-phenylalanine; tert-Butyloxycarbonyl-D-3-nitrophenylalanine
EINECS	Contact for details

Quality Control

Our Boc-D-3-Nitrophenylalanine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and spectroscopic identification. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee (D-isomer)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.