Description

Netrin-1 is a crucial laminin-related axon guidance molecule that plays a fundamental role in neuronal development and cellular migration. Its primary value lies in its ability to mediate chemoattractive and chemorepulsive signals during neural circuit formation, making it an essential research reagent in neurobiology. This protein is critically needed by researchers and developers in the fields of neuroscience, oncology, and regenerative medicine for studying neural development, cancer metastasis, and tissue repair mechanisms.

Application

• Neuroscience Research: Used as a key reagent in studies of axon guidance, neural development, and synaptic connectivity.
• Cancer Biology Studies: Investigated for its role in tumor cell migration, angiogenesis, and metastasis in various cancer models.
• Cell Migration & Chemotaxis Assays: Employed in in vitro assays to study the directional movement of neuronal and non-neuronal cells.
• Regenerative Medicine: Explored for its potential in promoting nerve regeneration and repair following injury.
• Drug Discovery Screening: Serves as a target or tool compound in high-throughput screens for novel therapeutics targeting Netrin-1 pathways.
• Biomaterial Functionalization: Used to coat surfaces or scaffolds to create permissive substrates for guided neurite outgrowth in tissue engineering.

Basic Information

Product Name	Netrin-1
CAS No.	158651-98-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Netrin1; NTN1; Netrin-1 Precursor; UNC-6; Netrin-1 Laminin Subunit; Axon Guidance Protein Netrin-1; DCC Ligand Netrin-1
EINECS	Contact for details

Quality Control

Our Netrin-1 is produced and tested under stringent quality management protocols to ensure batch-to-batch consistency and biological activity. Each lot is characterized for purity, identity, and functional performance. Certificates of Analysis (COA) detailing specific test results are available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive) and should be handled under appropriate conditions to prevent degradation. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Purity (SDS-PAGE)	> 95%
Identification (Mass Spec)	Conforms
Endotoxin Level	< 1.0 EU/µg
Biological Activity (Cell-based assay)	Contact for details
Solubility	Soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.