Description

A-Helical Corticotropin Releasing Factor (12-41) is a synthetic peptide fragment derived from the Corticotropin-Releasing Factor (CRF), a key neurohormone involved in the body's stress response. This specific fragment, corresponding to residues 12-41, is designed with an α-helical structure to serve as a potent and selective antagonist for CRF receptors. It is an essential research-grade biochemical tool for neuroscientists and pharmacologists studying stress-related disorders, anxiety, depression, and neuroendocrine pathways. The compound is supplied as a high-purity, lyophilized powder for reliable and reproducible experimental results.

Application

• Neuroscience Research: Used as a selective CRF receptor antagonist to study the role of CRF in stress response, anxiety, and depression models.
• Pharmacology & Drug Discovery: Serves as a reference standard and tool compound for screening and developing novel therapeutics targeting the CRF system.
• Endocrinology Studies: Investigates the modulation of the hypothalamic-pituitary-adrenal (HPA) axis and related hormone release.
• Behavioral Research: Applied in preclinical studies to understand the behavioral effects of CRF receptor blockade.
• Biochemical Assay Development: Utilized in the development and validation of receptor binding assays and other in vitro test systems.
• Academic & Institutional Research: A critical reagent for universities and research institutes focusing on neuropeptide signaling.

Basic Information

Item	Detail
Product Name	A-Helical Corticotropin Releasing Factor (12-41)
CAS No.	158535-55-8
Molecular Formula	C146H246N44O42
Molecular Weight	~3299.8 g/mol
Synonyms	α-Helical CRF (12-41); αh-CRF(12-41); A-Helical CRF (12-41); Astressin; Corticotropin-Releasing Factor (12-41), α-helical; CRF Antagonist (12-41); [DPhe12,Nle21,38,α-Me-Leu37]CRF(12-41); Astressin (human, rat)
EINECS	Contact for details

Quality Control

Our A-Helical Corticotropin Releasing Factor (12-41) is manufactured under strict quality protocols to ensure the highest standards for research applications. Each batch is subjected to comprehensive analytical testing, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. We provide a comprehensive Certificate of Analysis (COA) with each shipment, detailing purity, peptide content, and analytical data. Our quality system is designed to meet the rigorous demands of pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store the lyophilized powder at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption. For extended storage of solutions, aliquot and store at -20°C or lower. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, dilute acetic acid, or DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.