Description

ω-Agatoxin Tk is a potent and selective peptide neurotoxin originally isolated from the venom of the funnel-web spider, *Agelenopsis aperta*. This compound is a crucial pharmacological tool for the study of voltage-gated calcium channels (VGCCs), specifically blocking P/Q-type channels with high affinity. It is essential for researchers and developers in neuroscience, pharmacology, and drug discovery who require precise molecular tools to investigate synaptic transmission, neuronal excitability, and channelopathies.

Application

• Neuroscience Research: A selective blocker for studying the role of P/Q-type voltage-gated calcium channels in neurotransmitter release, synaptic plasticity, and neuronal signaling.
• Pharmacological Profiling: Used in high-throughput screening (HTS) and in vitro assays to identify and characterize novel calcium channel modulators or therapeutic candidates.
• Channelopathy Studies: Critical for modeling and understanding diseases linked to calcium channel dysfunction, such as certain forms of migraine, ataxia, and epilepsy.
• Electrophysiology: An indispensable tool for patch-clamp experiments to isolate and record P/Q-type calcium currents in neurons and other excitable cells.
• Biochemical Assays: Used in binding studies and competitive displacement assays to determine receptor affinity and specificity.
• Drug Discovery & Development: Serves as a reference standard and positive control in the development of new neuroactive pharmaceuticals targeting calcium channels.

Basic Information

Product Name	ω-Agatoxin Tk
CAS No.	158484-42-5
Molecular Formula	C184H274N52O55S7
Molecular Weight	~4280.9 g/mol
Synonyms	ω-Agatoxin TK; ω-Agatoxin TK; Agatoxin TK; P/Q-type Calcium Channel Blocker; Spider Toxin ω-Agatoxin Tk; Calcium Channel Toxin ω-Agatoxin Tk; Voltage-Gated Calcium Channel Inhibitor ω-Agatoxin Tk; Agelenin
EINECS	Contact for details

Quality Control

Our ω-Agatoxin Tk is produced under stringent conditions to ensure the highest standards of purity and biological activity for research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment, mass spectrometry for identity confirmation, and functional bioassays to verify specific channel-blocking activity. Certificates of Analysis (COA) detailing purity, potency, and analytical results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Potency (Functional Assay)	≥ 90% of stated activity
Water Content (KF)	≤ 5.0%
Endotoxin Level	< 1.0 EU/μg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.