Description

Coagulation Factor XIIIa (190-230) is a highly purified, activated fragment of the blood coagulation Factor XIII enzyme, a transglutaminase critical for hemostasis. This specific molecular weight fraction is essential for research and development in the fields of hematology, thrombosis, and fibrinolysis. It is a vital reagent for diagnostic assay manufacturers, pharmaceutical researchers, and academic institutions studying clot stabilization and wound healing processes.

Application

• Diagnostic Reagent Manufacturing: A key component in clinical diagnostic kits for assessing Factor XIII deficiency and related coagulation disorders.
• Biomedical Research: Used in in vitro studies to investigate the final stages of the blood coagulation cascade, fibrin cross-linking, and clot stability.
• Pharmaceutical Development: Serves as a reference standard and active ingredient in the development of therapeutic agents targeting hemostasis and wound healing.
• Enzymology Studies: Employed as a substrate or enzyme source in biochemical assays to study transglutaminase activity and enzyme kinetics.
• Quality Control (QC) Testing: Used as a calibrated standard in the QC laboratories of biopharmaceutical companies producing plasma-derived or recombinant coagulation factors.

Basic Information

Product Name	Coagulation Factor XIIIa (190-230)
CAS No.	158455-48-2
Molecular Formula	C950H1530N260O300S10 (Approximate for fragment)
Molecular Weight	~21 kDa (190-230 amino acid fragment)
Synonyms	Activated Blood Coagulation Factor XIII; Fibrin-Stabilizing Factor A Chain (activated); Plasma Transglutaminase (activated); F13A1 (activated); FXIIIa; Coagulation Factor XIII A Chain Fragment; Fibrinoligase; Protein-Glutamine γ-Glutamyltransferase A Chain
EINECS	Contact for details

Quality Control

Our Coagulation Factor XIIIa (190-230) is produced under stringent conditions to ensure high biological activity and purity, suitable for research and in vitro diagnostic use. Each batch is rigorously tested for identity, purity, and specific activity. A comprehensive Certificate of Analysis (COA) detailing assay results, including SDS-PAGE purity, functional activity, and endotoxin levels, is provided to guarantee traceability and compliance with your quality standards.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a dry environment before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (SDS-PAGE)	Single band at ~21 kDa
Purity (HPLC)	≥ 95%
Specific Activity	≥ XX U/mg (Contact for details)
Protein Content (Bradford)	≥ 90% of total mass
Endotoxin	< 1.0 EU/mg
Solubility	Soluble in aqueous buffers (e.g., Tris, PBS)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.