Description

2,2,2-Trifluoro-1-(3,4,5-Trichlorophenyl)Ethanone is a high-value trifluoromethyl ketone derivative, distinguished by its unique combination of halogenated aromatic and fluorinated alkyl groups. This compound is a critical advanced intermediate for synthesizing complex molecules in pharmaceutical and agrochemical research, where its structural motifs are leveraged to modulate biological activity and physicochemical properties. It is primarily sought by R&D chemists and process development scientists in the fine chemical and life science industries.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of specialty polymers and liquid crystals, where its halogenated structure can influence material properties.
• Fluorine Chemistry Studies: Acts as a model substrate in academic and industrial research exploring new fluorination methodologies and reaction mechanisms.

Basic Information

Product Name	2,2,2-Trifluoro-1-(3,4,5-Trichlorophenyl)Ethanone
CAS No.	158401-00-4
Molecular Formula	C8H2Cl3F3O
Molecular Weight	277.45 g/mol
Synonyms	1-(3,4,5-Trichlorophenyl)-2,2,2-trifluoroethanone; 3,4,5-Trichloro-α,α,α-trifluoroacetophenone; 2,2,2-Trifluoro-1-(3,4,5-trichlorophenyl)ethan-1-one; 3,4,5-Trichlorophenyl trifluoromethyl ketone; α,α,α-Trifluoro-3,4,5-trichloroacetophenone; Trifluoro(3,4,5-trichlorophenyl)methanone
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(3,4,5-Trichlorophenyl)Ethanone is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound may be sensitive to strong alkali and should be stored separately from incompatible materials. Keep the container tightly sealed when not in use to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.