Description

n-Methoxy-n-Methyl-1,4-Dioxaspiro[4.5]Decane-8-Carboxamide is a specialized organic compound belonging to the class of Weinreb amides, which are pivotal intermediates in modern synthetic organic chemistry. Its core value lies in its role as a highly effective acylating agent, enabling the controlled synthesis of ketones from various nucleophiles, including organometallic reagents. This compound is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require high-purity building blocks for complex molecule synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing spirocyclic or complex ketone motifs.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where its reactivity allows for the introduction of specific carbonyl functionalities.
• Organic Synthesis Reagent: Serves as a versatile N-Methoxy-N-methylamide (Weinreb amide) for the precise formation of ketones from Grignard reagents, organolithiums, and other carbanions.
• Material Science Research: Employed in the development of specialty polymers and organic electronic materials that require specific ketone precursors.
• Academic & R&D Laboratories: A valuable tool for methodological development and the synthesis of novel chemical entities in university and industrial research settings.
• Fine Chemical Production: Integral to the multi-step synthesis of flavors, fragrances, and other high-value specialty chemicals.

Basic Information

Product Name	n-Methoxy-n-Methyl-1,4-Dioxaspiro[4.5]Decane-8-Carboxamide
CAS No.	158243-48-2
Molecular Formula	C12H21NO4
Molecular Weight	243.30 g/mol
Synonyms	8-[(Methoxy(methyl)amino)carbonyl]-1,4-dioxaspiro[4.5]decane; 1,4-Dioxaspiro[4.5]decane-8-carboxylic acid, N-methoxy-N-methylamide; N-Methoxy-N-methyl-1,4-dioxaspiro[4.5]decane-8-carboxamide; Weinreb Amide of 1,4-Dioxaspiro[4.5]decane-8-carboxylic Acid; Spirocyclic Weinreb Amide; 8-(N-Methoxy-N-methylcarbamoyl)-1,4-dioxaspiro[4.5]decane; CAS 158243-48-2
EINECS	Contact for details

Quality Control

Our n-Methoxy-n-Methyl-1,4-Dioxaspiro[4.5]Decane-8-Carboxamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor purity grades to meet specific research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and reactivity. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.