Description

Boc-His(Boc)-Pro-Oh CAS NO 158211-50-8 is a protected dipeptide building block, specifically N-α-Boc-N-τ-Boc-L-histidyl-L-proline, widely used in solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring high-purity intermediates to construct complex peptide sequences with precise stereochemistry. It is an essential raw material for pharmaceutical R&D, particularly in the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of therapeutic peptide candidates targeting various diseases.
• Solid-Phase Peptide Synthesis (SPPS): Used in Fmoc/t-Boc chemistry to incorporate the His-Pro sequence while protecting reactive side chains.
• Biochemical Research: Serves as a standard or reagent in studies of enzyme substrates, inhibitors, and hormone analogs.
• Peptide Library Construction: Enables the combinatorial synthesis of diverse peptide libraries for drug discovery and screening.
• API Development: Intermediate in the multi-step synthesis of Active Pharmaceutical Ingredients (APIs) containing histidine and proline residues.
• Custom Peptide Services: A fundamental component for CROs and CDMOs offering bespoke peptide manufacturing.

Basic Information

Product Name	Boc-His(Boc)-Pro-Oh
CAS No.	158211-50-8
Molecular Formula	C₂₁H₃₄N₄O₇
Molecular Weight	454.52 g/mol
Synonyms	N-α-Boc-N-τ-Boc-L-histidyl-L-proline; Boc-L-His(Boc)-L-Pro-OH; (S)-2-((S)-2-((tert-Butoxycarbonyl)amino)-3-(3-((tert-butoxycarbonyl)amino)-1H-imidazol-1-yl)propanoyl)pyrrolidine-1-carboxylic acid; Boc-His(Boc)-Pro-OH; tert-Butyl (S)-1-((S)-2-((tert-butoxycarbonyl)amino)-3-(3-((tert-butoxycarbonyl)amino)-1H-imidazol-1-yl)propanoyl)pyrrolidine-2-carboxylate; BOC-HIS(BOC)-PRO; H-His(Boc)-Pro-OH.Boc; Protected His-Pro dipeptide
EINECS	Contact for details

Quality Control

Our Boc-His(Boc)-Pro-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via NMR and mass spectrometry. We provide a Certificate of Analysis (COA) with every shipment, detailing all critical specifications to ensure it meets the stringent requirements for pharmaceutical R&D and cGMP-guided production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere or with desiccant after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	95.0% - 102.0%
Specific Rotation	-40° to -50° (c=1 in DMF)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.