Description

3,4-Difluoro-5-Nitrophenylboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring both electron-withdrawing nitro and difluoro substituents, makes it an exceptionally versatile reagent for constructing complex molecular architectures. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for carbon-carbon bond formation.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the difluoro and nitro groups contribute to biological activity and metabolic stability.
• Material Science Research: Employed in the creation of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its ability to modify electronic properties.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Chemical Biology & Proteomics: Utilized in the design and synthesis of molecular probes and activity-based protein profiling (ABPP) agents for studying enzyme function.
• Custom Synthesis & Contract Manufacturing: A vital building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the global life sciences market.

Basic Information

Product Name	3,4-Difluoro-5-Nitrophenylboronic Acid
CAS No.	158178-36-0
Molecular Formula	C6H4BF2NO4
Molecular Weight	202.91 g/mol
Synonyms	(3,4-Difluoro-5-nitrophenyl)boronic acid; 5-Nitro-3,4-difluorobenzeneboronic acid; 3,4-Difluoro-5-nitrobenzeneboronic acid; Boronic acid, B-(3,4-difluoro-5-nitrophenyl)-; 158178-36-0; 3,4-Difluoro-5-nitrophenyl-B(OH)2; 5-Nitro-3,4-difluorophenylboronic acid
EINECS	Contact for details

Quality Control

Every batch of our 3,4-Difluoro-5-Nitrophenylboronic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive coupling reactions and regulatory filings. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are supplied with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Recommended storage temperature is 2-8°C for extended stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.