Description

Boc-Aminoisobutyric Acid Nca is a high-purity, protected amino acid derivative specifically designed for peptide synthesis. This compound is a critical building block for introducing the unique structural and conformational properties of α-aminoisobutyric acid (Aib) into peptide chains. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors who require precise control over peptide secondary structure, stability, and bioactivity. The product is supplied to meet the stringent demands of advanced research and GMP production environments.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected monomer for the automated synthesis of complex peptides containing Aib residues.
• Novel Therapeutic Peptide Development: Used to create peptide analogs with enhanced metabolic stability, membrane permeability, and helical propensity for drug discovery.
• Antimicrobial Peptide (AMP) Research: Incorporation of Aib can improve the proteolytic stability and helical structure of antimicrobial peptides.
• Peptidomimetics and Foldamers: Serves as a fundamental component in constructing foldamers that mimic protein secondary structures.
• Bioconjugation and Labeling: The reactive N-carboxyanhydride (NCA) group allows for controlled polymerization or site-specific conjugation under mild conditions.
• Material Science: Potential use as a monomer for synthesizing polypeptide-based biomaterials and coatings.

Basic Information

Product Name	Boc-Aminoisobutyric Acid Nca
CAS No.	158169-45-0
Molecular Formula	C10H15NO5
Molecular Weight	229.23 g/mol
Synonyms	Boc-Aib-NCA; (2-((tert-Butoxycarbonyl)amino)-2-methylpropanoic acid) N-carboxyanhydride; N-(tert-Butoxycarbonyl)-α-aminoisobutyric acid NCA; N-Boc-2-aminoisobutyric acid N-carboxyanhydride; Boc-Aminoisobutyric Acid N-Carboxyanhydride; tert-Butyl (1-(2,5-dioxooxazolidin-4-yl)-2-methylpropan-2-yl)carbamate; NCA of Boc-Aib-OH
EINECS	Contact for details

Quality Control

Our Boc-Aminoisobutyric Acid Nca is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive peptide synthesis. Each lot is analyzed to confirm identity, purity, and the absence of critical impurities like free acid or dipeptides. A comprehensive Certificate of Analysis (COA) detailing HPLC assay, chiral purity, and moisture content is provided with every shipment. We support compliance with cGMP and ICH guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its moisture-sensitive and light-sensitive nature. Allow the sealed container to equilibrate to room temperature before opening to minimize condensation and hydrolysis. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Solubility	Soluble in THF, DMF, DMSO; sparingly soluble in diethyl ether

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.