Description

(R)-5-Hydroxy Propafenone Hydrochloride CAS NO 158080-72-9 is a high-purity chiral intermediate and active pharmaceutical ingredient (API) metabolite. This compound is critical for pharmaceutical research and development, particularly in the study of drug metabolism and the synthesis of enantiomerically pure cardiovascular agents. It is primarily required by pharmaceutical manufacturers, R&D laboratories, and contract research organizations (CROs) engaged in the development of antiarrhythmic drugs and related metabolites.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of advanced antiarrhythmic agents.
• Active Pharmaceutical Ingredient (API) Metabolite: Used as a reference standard in pharmacokinetic and pharmacodynamic studies of Propafenone.
• Analytical Reference Standard: Serves as a high-purity calibrant in HPLC, LC-MS, and other analytical methods for drug impurity profiling and bioanalysis.
• Metabolite Research: Essential for studying the metabolic pathways, efficacy, and toxicity of Propafenone and its derivatives.
• Process Chemistry & Development: Utilized in route scouting and optimization for the commercial-scale production of enantiopure pharmaceuticals.
• Regulatory Submissions: Provides qualified material for use in stability studies and documentation required by agencies like the FDA and EMA.

Basic Information

Product Name	(R)-5-Hydroxy Propafenone Hydrochloride
CAS No.	158080-72-9
Molecular Formula	C22H30ClNO4
Molecular Weight	407.93 g/mol
Synonyms	(R)-5-Hydroxypropafenone HCl; 1-[2-Hydroxy-3-(propylamino)propoxy]-5-hydroxy-3-phenylpropiophenone Hydrochloride; (R)-5-OH-Propafenone Hydrochloride; Propafenone Metabolite 5-Hydroxy (R-enantiomer) Hydrochloride; (R)-N-Propyl-5-hydroxy-α-[2-(hydroxy)-3-(propylamino)propoxy]benzenepropanamine Hydrochloride; (R)-5-Hydroxy Propafenone HCl; 5-Hydroxypropafenone (R-isomer) Hydrochloride
EINECS	Contact for details

Quality Control

Our (R)-5-Hydroxy Propafenone Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical research. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure containers are sealed immediately after use to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R-enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.