Description

Fmoc-Ser(Tbu)-Osu CAS NO 158000-21-6 is a high-purity, protected amino acid derivative specifically engineered for solid-phase peptide synthesis (SPPS). This compound is critical for researchers and manufacturers requiring precise and efficient coupling reactions to build complex peptide sequences. It is an essential building block for pharmaceutical R&D, particularly in the development of therapeutic peptides, APIs, and novel bioconjugates.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected serine derivative with an active ester (OSu), it is a key reagent for the efficient, racemization-free incorporation of serine into growing peptide chains.
• Pharmaceutical Intermediate: Serves as a crucial building block in the research and commercial production of therapeutic peptides and active pharmaceutical ingredients (APIs).
• Bioconjugation and Labeling: Used in the site-specific modification of peptides and proteins for drug delivery systems, diagnostics, and biochemical probes.
• Combinatorial Chemistry: Employed in high-throughput screening libraries to discover new bioactive peptide leads.
• Academic and Industrial R&D: Essential for research in medicinal chemistry, biochemistry, and molecular biology focused on peptide structure-activity relationships.
• Custom Peptide Service Providers: A fundamental raw material for CROs and CDMOs offering bespoke peptide synthesis services.

Basic Information

Product Name	Fmoc-Ser(Tbu)-Osu
CAS No.	158000-21-6
Molecular Formula	C24H26N2O7
Molecular Weight	454.47 g/mol
Synonyms	Fmoc-Ser(O-t-Bu)-OSu; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-O-(tert-butyl)-L-serine N-hydroxysuccinimide ester; Fmoc-O-tert-butyl-L-serine succinimidyl ester; Fmoc-Ser(tBu)-OSu; Fmoc-L-Serine(O-t-butyl) N-succinimidyl ester; N-α-Fmoc-O-tert-butyl-L-serine N-succinimidyl ester; (2,5-Dioxopyrrolidin-1-yl) (2S)-3-[(2-methylpropan-2-yl)oxy]-2-[(9H-fluoren-9-ylmethoxy)formamido]propanoate
EINECS	Contact for details

Quality Control

Our Fmoc-Ser(Tbu)-Osu is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for advanced peptide synthesis. Each lot undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and reactivity. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.5%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.