Description

Pyrrolidine, 1-(Bromoacetyl)-2,5-Dimethyl-, cis- (9Ci) is a high-purity, functionalized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a versatile electrophilic reagent, enabling the introduction of a reactive bromoacetyl moiety onto a constrained pyrrolidine scaffold. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, particularly in medicinal chemistry programs targeting novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, particularly in the synthesis of protease inhibitors, receptor modulators, and other small-molecule therapeutics.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore new chemical space and introduce specific functional groups.
• Agrochemical Synthesis: Serves as a building block for creating novel active ingredients with potential herbicidal, fungicidal, or insecticidal properties.
• Chemical Biology Probes: Employed in the synthesis of molecular probes and affinity labels for studying enzyme mechanisms and protein-ligand interactions.
• Ligand and Catalyst Development: Useful for constructing sophisticated chiral ligands and organocatalysts based on the pyrrolidine core.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring this specific molecular handle.

Basic Information

Product Name	Pyrrolidine, 1-(Bromoacetyl)-2,5-Dimethyl-, cis- (9Ci)
CAS No.	157905-03-8
Molecular Formula	C8H14BrNO
Molecular Weight	220.11 g/mol
Synonyms	1-(Bromoacetyl)-2,5-dimethylpyrrolidine, cis-; cis-1-(Bromoacetyl)-2,5-dimethylpyrrolidine; 2,5-Dimethyl-1-(bromoacetyl)pyrrolidine; N-(Bromoacetyl)-2,5-dimethylpyrrolidine; Bromoacetyl-2,5-dimethylpyrrolidine; (cis)-1-(2-Bromoacetyl)-2,5-dimethylpyrrolidine; Pyrrolidine, 1-(bromoacetyl)-2,5-dimethyl-, (2R,5S)-rel-; A bromoacetyl pyrrolidine derivative.
EINECS	Contact for details

Quality Control

Our Pyrrolidine, 1-(Bromoacetyl)-2,5-Dimethyl-, cis- (9Ci) is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.