Description

Amyloid β-Protein (4-42) is a specific proteolytic fragment of the amyloid precursor protein (APP) and a key constituent of amyloid plaques. This peptide is of significant interest in neuroscience and Alzheimer's disease research, serving as a critical tool for studying the mechanisms of amyloid aggregation and neurotoxicity. It is primarily utilized by academic research institutions, pharmaceutical R&D departments, and biotechnology companies focused on neurodegenerative disorders and therapeutic development.

Application

• Biomedical Research: Fundamental studies on the aggregation kinetics, structure, and toxicity of amyloid-β peptides.
• Drug Discovery & Screening: Used as a target substrate in high-throughput assays to identify and validate potential inhibitors of amyloid aggregation.
• Antibody & Diagnostic Development: Serves as an antigen for generating and characterizing antibodies specific to Aβ(4-42), aiding in diagnostic assay development.
• Cell Culture & In Vitro Models: Application in neuronal cell culture studies to model amyloid-induced cytotoxicity and pathophysiological pathways.
• Biophysical Characterization: Analysis of peptide secondary structure, oligomer formation, and fibrillization using techniques like CD spectroscopy, FTIR, and electron microscopy.
• Animal Model Studies: Used in preclinical research to induce or study amyloid pathology in relevant animal models of Alzheimer's disease.

Basic Information

Product Name	Amyloid β-Protein (4-42)
CAS No.	157884-72-5
Molecular Formula	C185H282N50O57S
Molecular Weight	4134.6 g/mol
Synonyms	Aβ4-42; Aβ(4-42); Amyloid β-Protein (4-42); Amyloid-β (4-42); Amyloid Beta Peptide (4-42); β-Amyloid Protein (4-42); APP (672-713); Alzheimer's Disease Amyloid Peptide (4-42)
EINECS	Contact for details

Quality Control

Our Amyloid β-Protein (4-42) is produced and analyzed under stringent conditions to ensure high purity and batch-to-batch consistency, critical for reproducible research outcomes. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and analytical results. We adhere to rigorous quality standards suitable for research and development applications. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Molecular Weight	4134.6 ± 2.0 Da (MALDI-TOF MS)
Solubility	Soluble in water or dilute acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.