Description

2-Fluoro-3-(trifluoromethyl)phenylboron is a specialized organoboron reagent, a key building block in modern synthetic chemistry. Its value lies in enabling the precise construction of complex molecules through cross-coupling reactions, particularly the Suzuki-Miyaura reaction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients, as well as in advanced materials science for creating functional organic molecules.

Application

• Pharmaceutical Intermediate: A critical building block for synthesizing active pharmaceutical ingredients (APIs) containing fluorinated aromatic systems, which are prevalent in modern drug discovery.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the fluorine and trifluoromethyl groups enhance biological activity and stability.
• Material Science: Serves as a precursor for creating functional organic materials, such as liquid crystals, organic semiconductors, and polymers with tailored electronic properties.
• Suzuki-Miyaura Cross-Coupling: Primarily employed as a boronic acid or ester derivative in palladium-catalyzed cross-coupling reactions to form biaryl and other carbon-carbon bonds with high efficiency and selectivity.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D labs exploring new synthetic methodologies and creating compound libraries for screening.
• Ligand Synthesis: Used in the preparation of specialized ligands for catalysis and coordination chemistry.

Basic Information

Product Name	2-Fluoro-3-(trifluoromethyl)phenylboron
CAS No.	157834-21-4
Molecular Formula	C7H5BF4
Molecular Weight	171.92 g/mol
Synonyms	(2-Fluoro-3-(trifluoromethyl)phenyl)boronic acid; 2-Fluoro-3-(trifluoromethyl)benzeneboronic acid; [2-Fluoro-3-(trifluoromethyl)phenyl]boronic acid; Boronic acid, B-[2-fluoro-3-(trifluoromethyl)phenyl]-; 2-Fluoro-α,α,α-trifluoro-m-tolylboronic acid; 2-Fluoro-3-trifluoromethylphenylboronic acid
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-(trifluoromethyl)phenylboron is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.