Description

Nibentan CAS NO 157832-55-8 is a selective class III antiarrhythmic agent, functioning as a potassium channel blocker. This compound is of significant interest in pharmaceutical research and development for its potential in treating cardiac arrhythmias. It is primarily utilized by research institutions and pharmaceutical companies engaged in cardiovascular drug discovery and development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel antiarrhythmic drug candidates.
• Cardiovascular Research: Used as a reference standard or active compound in preclinical studies investigating potassium channel pharmacology.
• Biochemical Assay Development: Employed in the development of high-throughput screening assays for ion channel activity.
• Mechanistic Studies: Serves as a tool compound to study the role of specific potassium currents in cardiac electrophysiology.
• Academic Research: Utilized in university and institutional labs for fundamental research on cardiac ion channels and arrhythmia mechanisms.

Basic Information

Product Name	Nibentan
CAS No.	157832-55-8
Molecular Formula	C27H29N3O3S
Molecular Weight	475.60 g/mol
Synonyms	Nibentan; N-[2-(Diethylamino)ethyl]-4-[(2-methyl-1H-indol-3-yl)carbonyl]-1-piperazinecarbothioamide; 1-Piperazinecarbothioamide, N-[2-(diethylamino)ethyl]-4-[(2-methyl-1H-indol-3-yl)carbonyl]-; LU-111073; Antiarrhythmic Agent LU-111073
EINECS	Contact for details

Quality Control

Our Nibentan is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.