Description

Tamoxifen-Ethyl-D5 is a deuterated analog of the Tamoxifen metabolite, 4-Hydroxy-N-desmethyl Tamoxifen (Endoxifen), specifically labeled on the ethyl group. This compound serves as a critical internal standard for the precise quantification of Tamoxifen and its metabolites in biological matrices using advanced analytical techniques like LC-MS/MS. It is an essential tool for pharmaceutical R&D, clinical research, and bioanalytical laboratories focused on oncology drug development, therapeutic drug monitoring, and pharmacokinetic studies.

Application

• Bioanalytical Reference Standard: Primary use as an internal standard in Liquid Chromatography-Mass Spectrometry (LC-MS/MS) for the accurate measurement of Tamoxifen and its active metabolites in plasma, serum, and tissue samples.
• Pharmacokinetic & Metabolite Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Therapeutic Drug Monitoring (TDM): Supports the development and validation of assays to optimize Tamoxifen dosage for breast cancer patients based on individual metabolic profiles.
• Pharmaceutical Quality Control: Used in the analysis and quality assurance of Tamoxifen-based drug products and formulations.
• Forensic & Doping Control Analysis: Aids in the detection and confirmation of Tamoxifen, which is a prohibited substance in athletic competitions.
• Stable Isotope Labeling Research: Serves as a tracer in mechanistic studies to elucidate metabolic pathways and enzyme kinetics related to Tamoxifen biotransformation.

Basic Information

Product Name	Tamoxifen-Ethyl-D5
CAS No.	157698-32-3
Molecular Formula	C26H24D5NO2
Molecular Weight	~390.55 g/mol
Synonyms	4-Hydroxy-N-desmethyltamoxifen-d5 (Ethyl-d5); (Z)-4-Hydroxy-N-desmethyltamoxifen-d5; Endoxifen-d5 (Ethyl-d5); N-Desmethyl-4-hydroxytamoxifen-d5; 1-[4-[2-(Dimethylamino)ethoxy]phenyl]-1-(4-hydroxyphenyl)-2-phenyl-1-butene-d5; FC-1271a-d5; Metabolite E-d5
EINECS	Contact for details

Quality Control

Every batch of Tamoxifen-Ethyl-D5 CAS 157698-32-3 is manufactured and analyzed under strict quality management systems. We guarantee high chemical and isotopic purity suitable for sensitive analytical applications. Comprehensive testing includes identity confirmation (NMR, MS), purity assay (HPLC), and verification of deuterium incorporation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storage under an inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Isotopic Purity (D-content)	≥98 atom % D
Chemical Purity	≥95%
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.