Description

Fmoc-Phe-Ser(Tbu)-Oh CAS NO 157675-78-0 is a protected dipeptide building block, specifically an Fmoc-protected phenylalanyl-O-tert-butyl-serine derivative, essential for solid-phase peptide synthesis (SPPS). Its primary value lies in enabling the precise, sequential construction of complex peptides and proteins by providing orthogonal protection for the serine side chain, preventing unwanted side reactions. This high-purity intermediate is critically needed by pharmaceutical R&D teams, biotech companies, and CROs engaged in developing therapeutic peptides, peptide hormones, and research biochemicals.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block in the Fmoc/t-Bu strategy for the automated or manual synthesis of target peptide sequences.
• Pharmaceutical Research & Development: Used in the discovery and development of novel peptide-based therapeutics, including antimicrobial peptides (AMPs) and hormone analogs.
• Combinatorial Chemistry Libraries: Serves as a variable unit in the creation of diverse peptide libraries for high-throughput screening against biological targets.
• Bioconjugation & Peptide Engineering: Facilitates the site-specific introduction of the Phe-Ser sequence into larger constructs for drug delivery systems or biomaterials.
• Academic & Institutional Research: Employed in biochemistry and molecular biology laboratories for studying protein-protein interactions, enzyme substrates, and signal transduction pathways.
• Production of Custom Peptides: A critical raw material for contract manufacturing organizations (CMOs) specializing in the production of GMP-grade peptides for clinical trials.

Basic Information

Product Name	Fmoc-Phe-Ser(Tbu)-Oh
CAS No.	157675-78-0
Molecular Formula	C₃₁H₃₄N₂O₆
Molecular Weight	530.61 g/mol
Synonyms	Fmoc-Phe-Ser(tBu)-OH; Fmoc-L-Phenylalanyl-O-tert-butyl-L-serine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-phenylalanyl-O-(tert-butyl)-L-serine; Fmoc-Phenylalanine-O-tert-butyl-serine; Fmoc-Phe-Ser(OtBu)-OH; Nα-Fmoc-L-phenylalanyl-O-tert-butyl-L-serine; Fmoc-Phe-Ser(Trt)-OH analog (protected form); SPPS Dipeptide Building Block Fmoc-Phe-Ser(tBu)
EINECS	Contact for details

Quality Control

Every batch of Fmoc-Phe-Ser(Tbu)-Oh is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) detailing key parameters such as assay (HPLC), chiral purity, and residual solvent content. Our quality standards align with the requirements for pharmaceutical intermediates and non-GMP bioactive ingredients, supporting our commitment to supply reliability for critical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.