Description

1,4,7,10-Tetrakis(Aminocarbonylmethyl)-1,4,7,10-Tetraazacyclododecane is a highly functionalized macrocyclic chelating agent, a derivative of the versatile 1,4,7,10-tetraazacyclododecane (cyclen) platform. Its core value lies in its ability to form exceptionally stable complexes with a wide range of metal ions, making it a critical intermediate for advanced chemical synthesis. This compound is essential for researchers and manufacturers in the fields of magnetic resonance imaging (MRI) contrast agents, radiopharmaceuticals, catalysis, and supramolecular chemistry.

Application

• MRI Contrast Agent Precursor: Serves as a key intermediate for synthesizing high-relaxivity, gadolinium-based contrast agents (e.g., derivatives of Gadoteridol).
• Radiopharmaceutical Chelator: Used to develop bifunctional chelators for labeling peptides and antibodies with diagnostic (e.g., 68Ga, 64Cu) or therapeutic (e.g., 177Lu, 225Ac) radioisotopes.
• Catalyst Ligand: Functions as a multidentate ligand to create homogeneous catalysts for organic transformations and polymerization processes.
• Supramolecular Building Block: Employed in the construction of molecular cages, sensors, and host-guest complexes due to its pre-organized cavity and multiple binding sites.
• Metal Ion Scavenging/Sequestration: Utilized in analytical chemistry and environmental applications for selective metal ion extraction and detection.
• Chemical Research & Development: Acts as a versatile scaffold for developing new metal-organic frameworks (MOFs) and functional materials.

Basic Information

Product Name	1,4,7,10-Tetrakis(Aminocarbonylmethyl)-1,4,7,10-Tetraazacyclododecane
CAS No.	157599-02-5
Molecular Formula	C16H32N8O4
Molecular Weight	400.48 g/mol
Synonyms	1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid tetraamide; DOTA-tetraamide; Tetrakis(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane; DOTA-tetramide; 1,4,7,10-Tetra(carbamoylmethyl)-1,4,7,10-tetraazacyclododecane; Cyclen-tetraacetamide; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetamide; DOTA-NH2 (common abbreviation)
EINECS	Contact for details

Quality Control

Our production of 1,4,7,10-Tetrakis(Aminocarbonylmethyl)-1,4,7,10-Tetraazacyclododecane adheres to stringent quality protocols suitable for research and pharmaceutical intermediate applications. Each batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), residual solvents, and related substances are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.