Description

2-Cyclobuten-1-One, 3-Amino-2-Phenyl- is a specialized, high-value heterocyclic building block featuring a reactive amino-substituted cyclobutenone core fused with a phenyl group. This compound matters for its unique structural motif, which is pivotal in advanced organic synthesis, particularly for constructing complex molecular architectures and novel pharmacophores. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications in medicinal chemistry, ligand design, and the development of new synthetic methodologies.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) and bioactive molecules, particularly those requiring strained ring systems.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its unique scaffold for bioactivity.
• Material Science: Acts as a monomer or cross-linking agent in the research of advanced polymers and functional materials with specific thermal or optical properties.
• Medicinal Chemistry: Employed in high-throughput screening and structure-activity relationship (SAR) studies to explore new therapeutic targets.
• Academic & R&D: A valuable reagent for methodological development in organic synthesis, including cycloaddition reactions and ring-opening polymerizations.
• Chemical Biology: Utilized as a probe or labeling agent due to the reactivity of the amino and ketone functional groups.

Basic Information

Item	Detail
Product Name	2-Cyclobuten-1-One, 3-Amino-2-Phenyl-
CAS No.	157464-27-2
Molecular Formula	C10H9NO
Molecular Weight	159.19 g/mol
Synonyms	3-Amino-2-phenylcyclobut-2-en-1-one; 2-Phenyl-3-aminocyclobutenone; 3-Amino-2-phenyl-2-cyclobuten-1-one; 2-Cyclobuten-1-one, 3-amino-2-phenyl-; 157464-27-2; 3-Amino-2-phenyl-1-cyclobuten-1-one; Amino-phenylcyclobutenone
EINECS	Contact for details

Quality Control

Our 2-Cyclobuten-1-One, 3-Amino-2-Phenyl- is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term stability, storage at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) is recommended due to the potential sensitivity of the amino and enone functionalities.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.