Description

(2,2-Difluoro-Benzo[1,3]Dioxol-4-Yl)Acetonitrile is a high-value, fluorinated heterocyclic building block with the CAS registry number 157437-24-6. This compound is critical for introducing the difluoromethylenedioxy (O-CF2-O) pharmacophore into target molecules, a key structural motif known to enhance metabolic stability and membrane permeability. It is primarily sought after by pharmaceutical and agrochemical research organizations for the synthesis of novel active ingredients, including potential kinase inhibitors and advanced crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used to construct advanced fungicides and herbicides where the difluoromethylene bridge improves biological activity and environmental profile.
• Material Science Research: Serves as a precursor for specialty monomers or ligands in the development of novel polymers and catalysts.
• Chemical Biology Probes: Employed in the design of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Fluorine Chemistry: An important building block for academic and industrial research focused on incorporating fluorine atoms into complex organic architectures.

Basic Information

Product Name	(2,2-Difluoro-Benzo[1,3]Dioxol-4-Yl)Acetonitrile
CAS No.	157437-24-6
Molecular Formula	C9H5F2NO2
Molecular Weight	197.14 g/mol
Synonyms	4-(Cyanomethyl)-2,2-difluoro-1,3-benzodioxole; 2,2-Difluoro-1,3-benzodioxole-4-acetonitrile; (2,2-Difluoro-1,3-benzodioxol-4-yl)acetonitrile; 2,2-Difluorobenzo[d][1,3]dioxole-4-acetonitrile; 4-(Cyanomethyl)-2,2-difluorobenzo[d][1,3]dioxole; 157437-24-6; (2,2-Difluorobenzo[1,3]dioxol-4-yl)acetonitrile
EINECS	Contact for details

Quality Control

Our (2,2-Difluoro-Benzo[1,3]Dioxol-4-Yl)Acetonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material that meets the stringent requirements for pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥97.0%
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.