Description

Fmoc-Dl-Histidine CAS NO 157355-76-5 is a protected derivative of the amino acid histidine, featuring a 9-fluorenylmethoxycarbonyl (Fmoc) protecting group on the α-amino function. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptide chains. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the automated, stepwise construction of peptides.
• Pharmaceutical Research: Used in the development and production of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation: Serves as a key intermediate for attaching peptides to other molecules, surfaces, or carriers in bioconjugate chemistry.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive compounds.
• Biochemical Research: Utilized in studying protein-protein interactions, enzyme mechanisms, and structure-activity relationships (SAR).
• Antibody-Drug Conjugate (ADC) Development: Can be incorporated into linker-payload systems for targeted cancer therapies.

Basic Information

Product Name	Fmoc-Dl-Histidine
CAS No.	157355-76-5
Molecular Formula	C₂₁H₂₁N₃O₄
Molecular Weight	379.41 g/mol
Synonyms	Fmoc-His-OH; Fmoc-Histidine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-DL-histidine; Nα-Fmoc-DL-histidine; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-imidazol-4-yl)propanoic acid; DL-Fmoc-histidine; Fmoc-DL-His-OH; Fmoc-DL-Histidine
EINECS	Contact for details

Quality Control

Our Fmoc-Dl-Histidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and chiral analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting specifications for identity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Optical Purity (Chiral HPLC)	DL-mixture (Racemic)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.