Description

(E)-tert-Butyl 3-((Dimethylamino)Methylene)-4-Oxopyrrolidine-1-Carboxylate CAS NO 157327-42-9 is a high-purity, advanced pharmaceutical intermediate characterized by its specific enamine structure. This compound is of critical importance for its role as a key building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in oncology and antiviral research. It is primarily needed by R&D laboratories, process development chemists, and manufacturers in the pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for complex synthetic routes.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of novel drug candidates, especially those targeting kinase inhibition.
• API Synthesis: Serves as a key building block for constructing complex molecular scaffolds found in various therapeutic agents.
• Process Chemistry & Scale-Up: Used in route development and optimization from laboratory to pilot plant and commercial manufacturing scales.
• Research & Development: Essential for medicinal chemists in exploring new chemical entities and structure-activity relationships (SAR).
• Custom Synthesis: Employed in the contract manufacturing of specialized, high-value fine chemicals for client-specific projects.
• Chemical Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control.

Basic Information

Product Name	(E)-tert-Butyl 3-((Dimethylamino)Methylene)-4-Oxopyrrolidine-1-Carboxylate
CAS No.	157327-42-9
Molecular Formula	C12H20N2O3
Molecular Weight	240.30 g/mol
Synonyms	1-Boc-3-[(dimethylamino)methylene]-4-pyrrolidinone; tert-Butyl 3-[(dimethylamino)methylidene]-4-oxopyrrolidine-1-carboxylate; 1-(tert-Butoxycarbonyl)-3-[(dimethylamino)methylene]pyrrolidin-4-one; (E)-1-Boc-3-(dimethylaminomethylene)-4-pyrrolidinone; 3-[(Dimethylamino)methylene]-4-oxo-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester; Boc-3-(dimethylaminomethylene)-4-pyrrolidinone
EINECS	Contact for details

Quality Control

Our (E)-tert-Butyl 3-((Dimethylamino)Methylene)-4-Oxopyrrolidine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring a reliable supply for demanding pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.