Description

N2-iso-Butyroyl-3'-Deoxyguanosine is a chemically modified nucleoside derivative, specifically an acylated analog of deoxyguanosine, designed for advanced research and synthesis applications. This compound is a critical building block and reference standard in the development of oligonucleotide therapeutics and probes, where precise chemical modification is essential for tuning stability, binding affinity, and pharmacokinetic properties. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleic acid chemistry, antisense technology, and prodrug development.

Application

• Oligonucleotide Synthesis: Serves as a protected monomer for the solid-phase synthesis of modified DNA/RNA strands.
• Antisense & siRNA Research: Used to create nucleoside analogs that enhance nuclease resistance and target specificity in therapeutic oligonucleotides.
• Prodrug Development: Acts as a precursor in the design of nucleotide prodrugs for antiviral and anticancer applications.
• Biochemical Research: Functions as a substrate or inhibitor in enzymatic studies involving polymerases and nucleoside kinases.
• Diagnostic Probe Development: Incorporated into labeled probes for hybridization assays to improve detection sensitivity.
• Reference Standard: Provides a high-purity standard for analytical method development and quality control in pharmaceutical manufacturing.

Basic Information

Product Name	N2-iso-Butyroyl-3'-Deoxyguanosine
CAS No.	157025-66-6
Molecular Formula	C14H19N5O5
Molecular Weight	337.33 g/mol
Synonyms	3'-Deoxy-N2-isobutyrylguanosine; 3'-Deoxyguanosine, N2-(2-methylpropanoyl)-; N-Isobutyryl-3'-deoxyguanosine; 2-Amino-1,9-dihydro-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-6H-purin-6-one, N2-(2-methyl-1-oxopropyl)-; Isobutyryl-3'-deoxyguanosine; dG(ib) (common abbreviation); N2-Isobutyryl-2'-deoxyguanosine analog (related structure)
EINECS	Contact for details

Quality Control

Every batch of N2-iso-Butyroyl-3'-Deoxyguanosine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality system is designed to meet the exacting standards of pharmaceutical and life science research. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specifications such as HPLC purity, water content, and identity confirmation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.