Description

Cyclopropanemethanol, 1-Ethoxy-α-[(Trimethylsilyl)Ethynyl]- (9Ci) is a specialized organosilicon building block featuring a cyclopropane ring, an ethoxy group, and a trimethylsilyl-protected alkyne moiety. This compound is valued for its unique three-membered ring strain and the versatility of its protected ethynyl group, making it a critical intermediate in advanced synthetic chemistry. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring strained ring systems or alkyne functionality for click chemistry or further derivatization.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides where the cyclopropane motif can impart specific biological activity and stability.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the development of specialty polymers and advanced materials with tailored thermal or mechanical properties.
• Organic Synthesis Building Block: Employed in academic and industrial R&D for cyclopropanation reactions, Sonogashira couplings (after deprotection), and the construction of complex natural product analogs.
• Ligand and Catalyst Development: Utilized to create novel chiral ligands or organometallic catalysts where the rigid cyclopropane backbone induces stereoselectivity.

Basic Information

Product Name	Cyclopropanemethanol, 1-Ethoxy-α-[(Trimethylsilyl)Ethynyl]- (9Ci)
CAS No.	157022-44-1
Molecular Formula	C11H20O2Si
Molecular Weight	212.36 g/mol
Synonyms	1-Ethoxy-α-[(trimethylsilyl)ethynyl]cyclopropanemethanol; 1-Ethoxy-1-[(trimethylsilyl)ethynyl]cyclopropanemethanol; (1-Ethoxy-1-cyclopropyl-2-(trimethylsilyl)ethynyl)methanol; α-(Trimethylsilylethynyl)-1-ethoxycyclopropanemethanol; Cyclopropanemethanol, 1-ethoxy-α-[(trimethylsilyl)ethynyl]-; TMS-protected ethynylcyclopropanol ether
EINECS	Contact for details

Quality Control

Our production of Cyclopropanemethanol, 1-Ethoxy-α-[(Trimethylsilyl)Ethynyl]- (9Ci) adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is characterized using advanced analytical techniques including NMR, GC-MS, and HPLC. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile and light-sensitive nature, prolonged exposure to air, heat, or light should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.