Description

1-Palmitoyl-2-(Decanedioyl Mono-(2-Iodo-4-(3-Trifluoromethyl-3H-Diazirin-3-Yl)Benzyl)Ester)Glycero-3-Phosphocholine is a highly specialized, photoactivatable phospholipid derivative designed for advanced cross-linking studies in membrane biophysics and proteomics. Its core value lies in the trifluoromethyl-diazirine and aryl iodide moieties, which enable efficient, covalent labeling of biomolecules upon UV irradiation. This compound is essential for researchers and manufacturers in pharmaceutical R&D, lipidomics, and structural biology who require precise tools for investigating protein-lipid interactions and membrane protein topology.

Application

• Photoaffinity Labeling Probe: For covalent cross-linking and identification of lipid-binding proteins and membrane-associated targets in complex biological systems.
• Membrane Protein Research: Used to study the structure, dynamics, and lipid microenvironment of integral membrane proteins.
• Chemical Proteomics: A critical reagent for activity-based protein profiling (ABPP) to discover novel drug targets and off-target effects.
• Lipidomics & Metabolomics: Serves as a synthetic standard or a functionalized precursor for tracing metabolic pathways of complex lipids.
• Drug Discovery Platforms: Employed in high-throughput screening assays to characterize compound interactions with lipid bilayers and membrane receptors.
• Bioconjugation & Nanomaterial Functionalization: Facilitates the site-specific labeling of liposomes, nanoparticles, and other drug delivery vehicles for targeted therapy.

Basic Information

Item	Details
Product Name	1-Palmitoyl-2-(Decanedioyl Mono-(2-Iodo-4-(3-Trifluoromethyl-3H-Diazirin-3-Yl)Benzyl)Ester)Glycero-3-Phosphocholine
CAS No.	156996-76-8
Molecular Formula	C₄₃H₆₆F₃IN₃O₁₀P
Molecular Weight	1040.86 g/mol
Synonyms	Photoactivatable PC Lipid; Diazirine-Modified Phosphatidylcholine; TPD-PC (Trifluoromethyl Phenyl Diazirine Phosphatidylcholine); 1-Palmitoyl-2-(10-((2-Iodo-4-(3-(trifluoromethyl)-3H-diazirin-3-yl)benzyl)oxy)-10-oxodecanoyl)-sn-glycero-3-phosphocholine; Photo-Leucine-Like Phospholipid Probe; Membrane Cross-linker 156996-76-8; PED-6 Iodo-diazirine PC; Lipid-Based Photoaffinity Label
EINECS	Contact for details

Quality Control

Every batch of this high-purity biochemical is manufactured under strict quality protocols to ensure identity, potency, and consistency for sensitive research applications. Our rigorous analytical testing includes HPLC, NMR, and mass spectrometry to verify structural integrity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your regulatory and documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Due to its strictly light-sensitive and hygroscopic nature, store the product desiccated at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (NMR)	≥ 90%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.