Description

4-Benzyloxy-3,5-Difluorophenylboronic Acid is a high-purity organoboron compound, specifically a functionalized phenylboronic acid derivative. This chemical serves as a critical building block in modern synthetic chemistry, enabling the formation of carbon-carbon bonds via Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing difluorophenyl and benzyloxy motifs.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides requiring specific fluorinated aromatic structures.
• Material Science Research: Building block for creating novel organic electronic materials, liquid crystals, and polymers through palladium-catalyzed coupling.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and sensors that leverage boronic acid chemistry for diol recognition.
• Cross-Coupling Reactions: A versatile reagent in Suzuki-Miyaura cross-coupling for the efficient construction of biaryl and heterobiaryl systems in medicinal chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects at various scales.

Basic Information

Product Name	4-Benzyloxy-3,5-Difluorophenylboronic Acid
CAS No.	156635-88-0
Molecular Formula	C13H11BF2O3
Molecular Weight	264.04 g/mol
Synonyms	(4-(Benzyloxy)-3,5-difluorophenyl)boronic Acid; 3,5-Difluoro-4-(phenylmethoxy)benzeneboronic Acid; 4-(Benzyloxy)-3,5-difluorobenzeneboronic Acid; B-[4-(Benzyloxy)-3,5-difluorophenyl]boronic Acid; 156635-88-0; 4-Benzyloxy-3,5-difluorophenyl-Boronic Acid
EINECS	Contact for details

Quality Control

Our 4-Benzyloxy-3,5-Difluorophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets stringent specifications for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.