Description

Cadherin-11 is a calcium-dependent cell adhesion glycoprotein belonging to the type-II classical cadherin family, identified by CAS number 156621-71-5. This protein plays a critical role in mediating cell-cell interactions, specifically in tissue morphogenesis, osteoblast differentiation, and inflammatory responses. It is an essential research reagent for scientists in pharmaceutical R&D, cell biology, and oncology, particularly for studies on bone formation, rheumatoid arthritis, and cancer metastasis.

Application

• Biomedical Research: Used as a key reagent in studying cell adhesion mechanisms, tissue development, and morphogenesis.
• Drug Discovery & Development: Serves as a target protein for screening and validating therapeutic compounds aimed at modulating cadherin-mediated pathways.
• Cancer Research: Investigated for its role in tumor progression, metastasis, and epithelial-to-mesenchymal transition (EMT) in various cancers.
• Inflammation & Immunology Studies: Applied in research on rheumatoid arthritis and other inflammatory diseases where Cadherin-11 is implicated in synovial fibroblast adhesion.
• Bone Biology: Utilized in osteoblast research to understand bone formation and regeneration processes.
• Diagnostic Development: May be used in the development of immunoassays and diagnostic tools for diseases associated with cadherin expression.

Basic Information

Product Name	Cadherin-11
CAS No.	156621-71-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Cadherin 11; CDH11; OSF-4 (Osteoblast Cadherin); OB-Cadherin; Cadherin-11, type 2; Neural cadherin-like protein; PB-cadherin
EINECS	Contact for details

Quality Control

Our Cadherin-11 is produced and handled under stringent quality systems. Each batch undergoes comprehensive analytical testing, including purity assessment by HPLC and identity confirmation, to ensure consistency and biological activity suitable for research applications. A Certificate of Analysis (COA) detailing specific results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. Avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to standard
Purity (SDS-PAGE)	≥ 90%
Protein Content	≥ 95% (by UV absorbance)
Biological Activity	Assessed by cell adhesion assay
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in appropriate aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.