Description

1-Bromo-4-Ethoxy-2-(Trifluoromethyl)Benzene is a high-purity fluorinated aromatic building block, valued for its unique combination of bromo, ethoxy, and trifluoromethyl functional groups. This compound is essential for advanced organic synthesis, enabling the precise construction of complex molecules with tailored electronic and steric properties. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for applications in drug discovery, ligand synthesis, and the development of specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethylated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve biological activity and environmental persistence.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and polymers where fluorine substitution modifies electronic properties and solubility.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form biaryl structures.
• Chemical Biology Probes: Used to create fluorinated analogs of bioactive molecules for mechanistic studies and diagnostic applications.

Basic Information

Product Name	1-Bromo-4-Ethoxy-2-(Trifluoromethyl)Benzene
CAS No.	156605-95-7
Molecular Formula	C9H8BrF3O
Molecular Weight	269.06 g/mol
Synonyms	4-Bromo-1-ethoxy-2-(trifluoromethyl)benzene; 2-Bromo-5-ethoxy-α,α,α-trifluorotoluene; 1-Ethoxy-4-bromo-2-(trifluoromethyl)benzene; 2-Trifluoromethyl-4-bromophenetole; 4-Bromo-α,α,α-trifluoro-2-ethoxytoluene; Benzene, 1-bromo-4-ethoxy-2-(trifluoromethyl)-; p-Bromo-o-(trifluoromethyl)phenetole
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Ethoxy-2-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification results. Our quality commitment ensures the material meets the stringent requirements for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.