Description

1-Bromo-2-Ethoxy-4-(Trifluoromethyl)Benzene is a high-value halogenated aromatic building block of significant interest in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. Industrial researchers and process chemists need it for constructing active pharmaceutical ingredients (APIs), liquid crystal materials, and functional agrochemicals where the trifluoromethyl and bromo-ethoxy substitution pattern is critical for modulating biological activity and physicochemical properties.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Active Ingredient Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Liquid Crystal & OLED Material Development: Serves as a precursor for creating specialized aromatic cores in electronic display materials and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Stille) to form complex biaryl structures.
• Functional Material Research: Employed in the development of polymers, ligands for catalysis, and other specialty chemicals requiring a specific, multi-functionalized benzene ring.
• Chemical Research & Development: A valuable reagent for academic and industrial R&D labs exploring new synthetic methodologies and novel compound libraries.

Basic Information

Product Name	1-Bromo-2-Ethoxy-4-(Trifluoromethyl)Benzene
CAS No.	156605-94-6
Molecular Formula	C9H8BrF3O
Molecular Weight	269.06 g/mol
Synonyms	2-Bromo-1-ethoxy-4-(trifluoromethyl)benzene; 4-Bromo-3-ethoxybenzotrifluoride; 1-Bromo-2-ethoxy-4-(trifluoromethyl)benzene; 2-Ethoxy-α,α,α-trifluoro-p-bromotoluene; 3-Ethoxy-4-bromobenzotrifluoride; p-Bromo-o-ethoxybenzotrifluoride; Benzene, 1-bromo-2-ethoxy-4-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Ethoxy-4-(Trifluoromethyl)Benzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We can support development projects with custom purity grades, including standards suitable for GMP intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container should be kept tightly sealed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Individual Unknown Impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.