Description

1-(Difluoromethoxy)-4-(Trifluoromethyl)Benzene is a high-purity fluorinated aromatic building block of significant interest in advanced chemical synthesis. Its unique structure, featuring both difluoromethoxy and trifluoromethyl substituents, makes it a valuable intermediate for introducing fluorine atoms into target molecules, which can dramatically alter their physical, chemical, and biological properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced metabolic stability, bioavailability, and lipophilicity.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides where the fluorine motifs improve efficacy and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs) due to its influence on electronic properties and stability.
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to develop specialty polymers with enhanced chemical resistance, thermal stability, and unique surface properties.
• Organic Synthesis & Catalysis Research: A versatile reagent in academic and industrial laboratories for exploring new fluorination methodologies and catalytic cycles.
• Material Science Additive: Investigated for use in coatings and composites to impart specific dielectric or hydrophobic characteristics.

Basic Information

Product Name	1-(Difluoromethoxy)-4-(Trifluoromethyl)Benzene
CAS No.	156570-16-0
Molecular Formula	C8H5F5O
Molecular Weight	212.12 g/mol
Synonyms	α,α-Difluoro-4-(trifluoromethyl)anisole; 4-(Trifluoromethyl)phenyl Difluoromethyl Ether; p-(Trifluoromethyl)difluoromethoxybenzene; 1-Difluoromethoxy-4-trifluoromethylbenzene; Difluoromethoxy(trifluoromethyl)benzene; Benzene, 1-(difluoromethoxy)-4-(trifluoromethyl)-; DFMTFB
EINECS	Contact for details

Quality Control

Our production of 1-(Difluoromethoxy)-4-(Trifluoromethyl)Benzene adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including GC, HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical parameters. Our quality system is designed to meet the exacting standards required for pharmaceutical and advanced material research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area. Recommended storage temperature is 2-8°C for long-term stability. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.