Description

Tracheobronchial Mucin 5 is a high-purity glycoprotein isolated from the respiratory tract, specifically the tracheobronchial region. This compound is essential for research and development in pulmonary biology, serving as a critical model for studying mucus composition, airway defense mechanisms, and the pathophysiology of respiratory diseases. It is primarily utilized by biopharmaceutical companies, academic research institutions, and diagnostic developers focused on cystic fibrosis, chronic obstructive pulmonary disease (COPD), asthma, and respiratory infection models.

Application

• Respiratory Disease Research: Fundamental studies on mucus biophysics, viscoelasticity, and barrier function in conditions like cystic fibrosis, COPD, and asthma.
• Drug Delivery & Formulation: Used as a substrate to test the penetration and efficacy of inhaled pharmaceuticals, including mucolytics, antibiotics, and anti-inflammatory agents.
• In Vitro Model Development: A key component in creating advanced 3D cell cultures, organ-on-a-chip systems, and artificial mucus layers for more physiologically relevant testing.
• Diagnostic Assay Development: Serves as a standard or coating antigen in immunoassays and biosensors designed to detect specific mucin antibodies or alterations associated with disease.
• Host-Pathogen Interaction Studies: Investigates how bacteria, viruses, and fungi adhere to and interact with the mucosal surface of the airways.
• Biomaterial & Medical Device Testing: Evaluates the biocompatibility and fouling resistance of materials intended for use in respiratory devices (e.g., ventilators, inhalers).

Basic Information

Product Name	Tracheobronchial Mucin 5
CAS No.	156533-23-2
Molecular Formula	Contact for details
Molecular Weight	High Molecular Weight Glycoprotein
Synonyms	MUC5B; Mucin 5 Subtype B, Tracheobronchial; Tracheobronchial Mucin; MUC5B Mucin; Respiratory Mucin 5B; High Molecular Weight Mucin; Airway Mucin Glycoprotein; Gastric Mucin 5B (related)
EINECS	Contact for details

Quality Control

Our Tracheobronchial Mucin 5 is produced and handled under strict quality protocols to ensure batch-to-batch consistency and biological activity. Each lot is characterized for key parameters including protein content, carbohydrate composition, and viscosity profile. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional assays is provided with every shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or lyophilized solid
Identification (IR / Electrophoresis)	Conforms to standard
Protein Content (BCA / Lowry)	≥ 85%
Carbohydrate Content (Phenol-Sulfuric Acid)	10 - 20%
Sialic Acid Content	Reported on COA
Solubility	Soluble in appropriate buffers (e.g., PBS, Tris)
Biological Activity (Viscosity)	Reported on COA
Endotoxin Level (LAL)	< 1.0 EU/mg
Microbial Bioburden	To specification

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.