Description

Neurexin Ibeta CAS NO 156532-80-8 is a synthetic peptide fragment derived from the neurexin family of neuronal cell surface proteins, which play a critical role in synapse formation and function. This high-purity biochemical is essential for advanced neuroscience research, enabling the study of protein-protein interactions at the synaptic cleft. It is primarily utilized by research institutions and pharmaceutical R&D departments focused on neurodevelopmental disorders, synaptic plasticity, and novel therapeutic target identification.

Application

• Neuroscience Research: A key reagent for studying the molecular mechanisms of synapse assembly, specifically the interaction between neurexins and neuroligins.
• Biochemical Assay Development: Used as a standard or binding partner in ELISA, surface plasmon resonance (SPR), and pull-down assays to quantify protein interactions.
• Drug Discovery Screening: Serves as a target for high-throughput screening (HTS) campaigns aimed at identifying small molecules or biologics that modulate synaptic adhesion pathways.
• Academic & Institutional Studies: Fundamental tool for investigating the etiology of autism spectrum disorders (ASD), schizophrenia, and other conditions linked to synaptic dysfunction.
• Proteomics and Structural Biology: Used in X-ray crystallography or NMR studies to map binding domains and understand the structural basis of synaptic connectivity.
• Diagnostic Development: Potential use in developing assays for detecting autoantibodies or biomarkers related to neurological diseases.

Basic Information

Product Name	Neurexin Ibeta
CAS No.	156532-80-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Neurexin-1-beta; Neurexin I beta; β-Neurexin I; NRXN1beta; Neuronal surface protein neurexin 1-beta; Synaptic cell surface protein
EINECS	Contact for details

Quality Control

Our Neurexin Ibeta is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including mass spectrometry for sequence confirmation and purity assessment via reverse-phase HPLC. Certificates of Analysis (COA) detailing purity, peptide content, and endotoxin levels are provided to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider aliquoting to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (MS)	Consistent with theoretical molecular weight
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Solubility	Soluble in water or appropriate aqueous buffer
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.