Description

(3S,4S)-(-)-1-Benzyl-3,4-Bis(Diphenylphosphino)Pyrrolidine CAS NO 156517-64-5 is a high-value, chiral bisphosphine ligand essential for asymmetric catalysis. Its primary value lies in enabling highly enantioselective transformations, critical for producing single-isomer intermediates in pharmaceutical and fine chemical synthesis. This product is specifically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require precise stereochemical control in hydrogenation, cross-coupling, and hydroformylation reactions.

Application

• Asymmetric Hydrogenation Catalysis: A key ligand for the enantioselective reduction of prochiral olefins, enamines, and ketones to produce chiral alcohols and amines.
• Pharmaceutical Intermediate Synthesis: Used in the production of active pharmaceutical ingredients (APIs) where high enantiomeric purity is mandated.
• Cross-Coupling Reactions: Facilitates asymmetric versions of Suzuki, Heck, and other C-C bond-forming reactions.
• Hydroformylation Processes: Employed in the synthesis of chiral aldehydes from olefins.
• Agrochemical Manufacturing: For creating enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic and Industrial R&D: A vital tool for developing new catalytic methodologies and exploring novel synthetic routes.

Basic Information

Product Name	(3S,4S)-(-)-1-Benzyl-3,4-Bis(Diphenylphosphino)Pyrrolidine
CAS No.	156517-64-5
Molecular Formula	C41H37P2
Molecular Weight	590.69 g/mol
Synonyms	(3S,4S)-(-)-1-Benzyl-3,4-bis(diphenylphosphino)pyrrolidine; (S,S)-(-)-1-Benzyl-3,4-bis(diphenylphosphino)pyrrolidine; (S,S)-BDPP; (S,S)-1-Benzyl-3,4-bis(diphenylphosphino)pyrrolidine; (3S,4S)-BDPP; (-)-BDPP; ChiraPhos; JosiPhos ligand analogue; 1-Benzyl-3,4-bis(diphenylphosphino)-(3S,4S)-pyrrolidine
EINECS	Contact for details

Quality Control

Every batch of our (3S,4S)-(-)-1-Benzyl-3,4-Bis(Diphenylphosphino)Pyrrolidine is manufactured and tested under strict quality management systems to ensure exceptional purity and chiral integrity, suitable for sensitive catalytic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as chemical purity, enantiomeric excess, and specific rotation. Our quality commitment aligns with the standards required for cGMP and ISO-guided manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store under an inert atmosphere (argon or nitrogen) at 2-8°C. This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light). Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Specific Rotation [α]	-80° to -90° (c=1 in CHCl3)
Melting Point	158 - 162 °C
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.