Description

2,3-Difluoro-1-Iodo-4-Methoxybenzene is a high-purity, multi-functional halogenated aromatic building block essential for advanced organic synthesis. Its unique combination of fluorine, iodine, and methoxy substituents makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is particularly valuable for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries, where it is used to develop new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for fluorine-containing drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Research: Used in the development of next-generation herbicides, fungicides, and pesticides, where the difluoro and iodo groups can enhance biological activity and environmental stability.
• Ligand & Catalyst Preparation: Serves as a precursor for sophisticated ligands in transition metal catalysis, enabling challenging cross-coupling and C-H activation reactions.
• Liquid Crystal & OLED Materials: A building block for fluorine-doped organic electronic materials, contributing to improved charge transport and emission properties in display technologies.
• Radiolabeling Precursor: The iodine atom provides a potential site for radioiodination (e.g., I-125, I-131) in the development of diagnostic imaging agents and radiopharmaceuticals.
• Advanced Polymer Chemistry: Incorporated into specialty polymer backbones to impart specific characteristics like chemical resistance, thermal stability, or unique optical properties.

Basic Information

Product Name	2,3-Difluoro-1-Iodo-4-Methoxybenzene
CAS No.	156499-64-8
Molecular Formula	C7H5F2IO
Molecular Weight	269.02 g/mol
Synonyms	1-Iodo-2,3-difluoro-4-methoxybenzene; 2,3-Difluoro-4-methoxyiodobenzene; 4-Methoxy-2,3-difluoroiodobenzene; 156499-64-8; Benzene, 2,3-difluoro-1-iodo-4-methoxy-; 2,3-Difluoroanisole, 6-iodo-; 6-Iodo-2,3-difluoroanisole
EINECS	Contact for details

Quality Control

Every batch of 2,3-Difluoro-1-Iodo-4-Methoxybenzene is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles via techniques such as HPLC, GC, NMR, and mass spectrometry is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Melting Point	Contact for details
Heavy Metals	<20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.